Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 January 1947:
Vol. 105. no. 2717, pp. 94 - 95
DOI: 10.1126/science.105.2717.94
Prev | Table of Contents | Next

Articles

New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin

KARL H. BEYER 1

1 Department of Pharmacology, Sharp & Dokme, Inc., Glenolden, Pennsylvania

It has been found that the excretion of penicillin by a renal tubular transport mechanism could be physiologically inhibited reversibly. The basis for this effect is thought to be one of substrate competition between penicillin, which is excreted by the tubules, and 4'-carboxyphenyl-methanesulfonanilide, which is essentially refractory to excretion by that transport mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
PENICILLIN-CARONAMIDE THERAPY OF ENTEROCOCCUS ENDOCARDITIS.
R. P. HAGER, E. J. HEITZMAN, and R. M. YOUNG (1951)
Ann Intern Med 34, 510-516
   Abstract »    PDF »
CARONAMIDE AND PENICILLIN: Serum Levels in Human Beings, Following Multiple Doses of the Drugs.
M. MEADS, R. V. LONG, S. H. PACE, and G. T. HARRELL (1948)
JAMA 138, 874-877
   Abstract »    PDF »
SYPHILIS: A Review of the Recent Literature.
F. W. REYNOLDS and J. E. MOORE (1947)
Arch Intern Med 80, 799-840
   Abstract »    PDF »
CARONAMIDE FOR INCREASING PENICILLIN PLASMA CONCENTRATIONS IN MAN.
J. W. CROSSON, W. P. BOGER, C. C. SHAW, and A. K. MILLER (1947)
JAMA 134, 1528-1532
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)