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Science 6 September 1946:
Vol. 104. no. 2697, pp. 220 - 221
DOI: 10.1126/science.104.2697.220
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Articles

Effect of Some Sulfhydryl-containing Substances on the Toxicity of an Organic Mercurial Compound

W. K. LONG 1 and A. FARAH 1

1 Department of Pharmacology, Harvard Medical School, and Thorndike Memorial Laboratory, Second and Fourth Medical Services (Harvard), Boston City Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts

The acute toxicity of an organic mercurial as studied on the mouse, intact anesthetized cat and dog, and the heart-lung preparation of the dog can be readily counteracted by sulfhydryl-containing compounds such as glutathione, cysteine, and 2,3-dimercapto-propanol. Equimolar doses of 2,3-dimercapto-propanol are about five times as active as cysteine or glutathione.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)