Influence of Anesthesia on Experimental Western Equine Encephalomyelitis
S. EDWARD SULKIN 1,
ANDRES GOTH 1, and
CHRISTINE ZARAFONETIS 1
1 Departments of Bacteriology and Immunology, and Physiology and Pharmacology, Southwestern Medical College, Dallas, Texas
Anesthesia, by ether, is effective in the treatment of western equine encephalomyelitis in mice. Of mice treated with deep ether anesthesia soon after the intracerebral injection of western equine virus, only 58 per cent developed the disease as compared with 92.4 per cent of control animals. When anesthesia was delayed the approximate length of the incubation period, 60 per cent of the animals developed the disease as compared with 92.4 per cent of the controls. In addition, ether anesthesia delays the development of central nervous system symptoms not only when administered soon after the injection of the virus but also when administered after the disease has progressed far enough to cause objective signs of encephalitis.
