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Science 26 April 1946:
Vol. 103. no. 2678, pp. 497 - 498
DOI: 10.1126/science.103.2678.497
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Articles

Distemperoid Virus Interference in Canine Distemper

ROBERT G. GREEN 1 and CYRIL S. STULBERG 1

1 Department of Bacteriology and Immunology, University of Minnesota Medical School, Minneapolis

A distemper virus modified by ferret passage so as to become a harmless vaccine for foxes and dogs exhibits the interference or cell-blockade phenomenon with respect to a virulent distemper infection in foxes. Ten control foxes receiving virulent distemper virus died, while 30 foxes receiving distemperoid virus in addition lived.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)