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Science 14 December 1945:
Vol. 102. no. 2659, pp. 618 - 619
DOI: 10.1126/science.102.2659.618
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Articles

HEATED, AVIRULENT ANTIGENS FOR COMPLEMENT-FIXATION TESTS WITH CERTAIN ENCEPHALITIS VIRUSES

J. CASALS 1

1 THE ROCKEFELLER INSTITUTE FOR MEDICAL RESEARCH, NEW YORK, N. Y.

A simple method is described for producing avirulent mouse brain antigens for complement-fixation tests in human encephalitides, by application of heat at 60° C for 30 minutes. The heated antigens retain for most of the viruses employed a sufficiently high titer to warrant their use, since they are also specific, not anticomplementary, can be lyophilized and moreover, are avirulent, and thus can be handled with safety.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)