Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 12 October 1945:
Vol. 102. no. 2650, pp. 376 - 377
DOI: 10.1126/science.102.2650.376
Prev | Table of Contents | Next

Articles

BACITRACIN: A NEW ANTIBIOTIC PRODUCED BY A MEMBER OF THE B. SUBTILIS GROUP

BALBINA A. JOHNSON 1, HERBERT ANKER 1, and FRANK L. MELENEY 1

1 DEPARTMENTS OF SURGERY AND BIOCHEMISTRY, COLLEGE OF PHYSICIANS AND SURGEONS, COLUMBIA UNIVERSITY

A new antibiotic "bacitracin" has been recovered from a strain of the B. subtilis group of organisms. It is neutral, water-soluble, non-toxic and relatively heat stable. In vitro it is active chiefly against Grampositive organisms, but the gonococcus and meningococcus are susceptible to its action. It is also active in vivo against experimentally produced hemolytic streptococcal infections in mice and gas gangrene infections in guinea pigs. Clinical use in hemolytic streptococcal and staphylococcal infections in man have given encouraging results.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Bacitracin-Resistant Bacillus subtilis Gene Encodes a Homologue of the Membrane-Spanning Subunit of the Bacillus licheniformis ABC Transporter.
R. Ohki, K. Tateno, Y. Okada, H. Okajima, K. Asai, Y. Sadaie, M. Murata, and T. Aiso (2003)
J. Bacteriol. 185, 51-59
   Abstract »    Full Text »    PDF »
Regulation of the Bacillus subtilis bcrC Bacitracin Resistance Gene by Two Extracytoplasmic Function {sigma} Factors.
M. Cao and J. D. Helmann (2002)
J. Bacteriol. 184, 6123-6129
   Abstract »    Full Text »    PDF »
Frank L. Meleney: Pioneer Surgeon-Bacteriologist: Presidential Address.
W. R. Sandusky (1983)
Arch Surg 118, 151-155
   Abstract »    PDF »
BACITRACIN NEPHROPATHY: REPORT OF A CASE OF ACUTE RENAL FAILURE AND DEATH.
G. Genkins, J. W. Uhr, and M. S. Bryer (1954)
JAMA 155, 894-897
   Abstract »    PDF »
USE OF ANTIBIOTICS IN GASTROINTESTINAL DISEASES: A Review.
J. B. KIRSNER, E. LEVIN, and W. L. PALMER (1952)
Arch Intern Med 90, 677-706
   Abstract »    PDF »
DIPHTHEROID SUBACUTE BACTERIAL ENDOCARDITIS SUCCESSFULLY TREATED WITH BACITRACIN.
J. F. ZENDEL and A. LUBART (1952)
Arch Intern Med 90, 562-568
   Abstract »    PDF »
CLINICAL EXPERIENCE WITH ``POLYCIN,'' A POLYMYXIN-BACITRACIN OINTMENT.
F. M. GASTINEAU and H. J. FLORESTANO (1952)
Arch Dermatol 66, 70-75
   Abstract »    PDF »
TREATMENT OF PYODERMAS WITH PENICILLIN 92: Comparison with Neomycin and Bacitracin.
H. RATTNER and H. H. RODIN (1952)
Arch Dermatol 65, 656-662
   Abstract »    PDF »
COMBINED ANTIBIOTIC THERAPY: Report of a Case of Subacute Bacterial Endocarditis Reinfected with a Diphtheroid and Successfully Treated with Penicillin and Bacitracin.
R. WALLACH and N. POMERANTZ (1951)
Arch Intern Med 88, 840-846
   Abstract »    PDF »
THE TREATMENT OF PNEUMONIA WITH BACITRACIN.
E. H. REISNER JR., F. N. BAILEY, and E. APPELBAUM (1951)
Ann Intern Med 34, 1232-1242
   Abstract »    PDF »
FURTHER EXPERIENCES IN TREATMENT OF SEPTIC MENINGITIS WITH BACITRACIN.
P. TENG (1950)
Arch Neurol Psychiatry 64, 861-877
   Abstract »    PDF »
BRAIN ABSCESS AND MENINGITIS ASSOCIATED WITH A PLEUROPNEUMONIA-LIKE ORGANISM: CLINICAL AND BACTERIOLOGICAL OBSERVATIONS IN A CASE WITH RECOVERY.
T. F. PAINE JR., R. MURRAY, I. PERLMUTTER, and M. FINLAND (1950)
Ann Intern Med 32, 554-562
   Abstract »    PDF »
STUDIES ON POLYPEPTIDES AND AMINO ACIDS BY COUNTERCURRENT DISTRIBUTION.
L. C. Craig, J. D. Gregory, and G. T. Barry (1950)
Cold Spring Harb Symp Quant Biol 14, 24-31
   Abstract »    PDF »
TOPICAL BACITRACIN THERAPY OF PYOGENIC DERMATOSES: A Clinical Report.
J. L. DERZAVIS, J. S. RICE, and L. S. LELAND (1949)
JAMA 141, 191-192
   Abstract »    PDF »
BACITRACIN: Its Topical Use in Aural and Pharyngeal Infections.
J. E. COYLE, K. COLLINS, and W. J. NUNGESTER (1949)
Arch Otolaryngol Head Neck Surg 50, 284-289
   Abstract »    PDF »
EVALUATION OF BACITRACIN IN LOCAL TREATMENT OF PYOGENIC INFECTIONS.
J. L. MILLER, M. H. SLATKIN, and B. A. JOHNSON (1949)
Arch Dermatol 60, 106-120
   Abstract »    PDF »
BACITRACIN THERAPY: The First Hundred Cases of Surgical Infections Treated Locally with the Antibiotic.
F. L. MELENEY and B. JOHNSON (1947)
JAMA 133, 675-680
   Abstract »    PDF »
INFECTIOUS DISEASES: Twelfth Annual Review of Significant Publications.
H. A. REIMANN (1946)
Arch Intern Med 78, 447-494
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)