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Science 15 June 1945:
Vol. 101. no. 2633, pp. 618 - 619
DOI: 10.1126/science.101.2633.618
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Articles

ORAL PENICILLIN WITH BASIC ALUMINUM AMINOACETATE

JOHN C. KRANTZ JR. 1, WILLIAM E. EVANS JR. 1, and JAMES G. MCALPINE 1

1 SCHOOL OF MEDICINE, UNIVERSITY OF MARYLAND, BALTIMORE, MD.

This method appears to be suitable for the oral administration of penicillin. Basic aluminum aminoacetate seems admirably suited for this purpose. It is neutral and buffers gastric acidity to pH 4 to 4.5. While this work was in progress McDermott et al.6 successfully employed magnesium trisilicate in this manner.

Clinical work is now in progress using the combination in infections known to be susceptible to parenteral penicillin therapy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ORAL ADMINISTRATION OF PENICILLIN IN PEDIATRICS.
H. A. REISMAN, A. A. GOLDFARB, and M. MOLLOY (1947)
Arch Pediatr Adolesc Med 74, 19-31
   Abstract »    PDF »
Urinary Recovery of Penicillin After Oral Administration With Antacids and Buffers.
M. J. GOLDEN and F. M. NEUMEIER (1946)
Science 104, 102-104
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)