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Science 1 September 1944:
Vol. 100. no. 2592, pp. 198 - 200
DOI: 10.1126/science.100.2592.198
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Articles

INHIBITION OF beta HEMOLYTIC STREPTOCOCCI FIBRINOLYSIN BY TRYPSIN INHIBITOR (ANTIPROTEASE)

I. ARTHUR MIRSKY 1

1 Major, M.C., A.U.S., AAF REGIONAL STATION HOSPITAL, LINCOLN ARMY AIR FIELD, LINCOLN, NKBR.

Crystalline "trypsin-inhibitor" of pancreatic origin and the antitrypsin of soybean origin completely inhibit the fibrinolytic activity of cultures of beta hemolytic streptococci, of filtrates of such cultures and of concentrates of such filtrates. It is suggested that the streptococcal fibrinolysin is a protease and that it may be related to trypsin.

The author wishes to acknowledge gratefully the cooperation of Lieutenant Colonel Robert L. King, Lieutenant Colonel E. D. Embree and Captain Edward Freis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DYNAMICS OF THE ACTION OF PENICILLIN IN EXPERIMENTAL ANIMALS: Observations on Mice.
E. JAWETZ (1946)
Arch Intern Med 77, 1-15
   Abstract »    PDF »
CRYSTALLIZATION OF A TRYPSIN INHIBITOR FROM SOYBEAN.
M. KUNITZ (1945)
Science 101, 668-669
   PDF »
RELATIONSHIP BETWEEN PATHOGENICITY AND pH TOLERANCE OF MICROORGANISMS.
J. M. LEISE and L. H. JAMES (1945)
Science 101, 437-438
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)