Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Special Online Collection: Cell Signaling 2008

Jump to features in special collection:

Cell Signaling 2008In this October 2008 special feature, Science and Science Signaling team up to explore the state of the art in recent research on the complex biochemical signals that regulate living cells. In the 17 October issue of Science, three Review articles examine regulatory feedback loops and the insights being gained on signaling through new modeling and lab techniques. In the 21 October issue of Science Signaling, Perspectives look at the role of scaffolding molecules in pathway responses, how pulsatile inputs can shed light on dynamic signaling behaviors, and how advances in chemical approaches are also offering deeper insights. And an original research paper shows how ideas gleaned from the world of digital-circuit engineering can be applied to biological systems.

In Science

INTRODUCTION

Getting Your Loops Straight >
L. Bryan Ray

REVIEWS

Feedback Loops Shape Cellular Signals in Space and Time >
Onn Brandman, Tobias Meyer
Biological regulatory networks often have feedback loops that determine fundamental properties of the physiological events they control.

REVIEWS

Optical Switches for Remote and Noninvasive Control of Cell Signaling >
Pau Gorostiza, Ehud Y. Isacoff
Turning on or off the activity of a protein with light offers precise control necessary to explore dynamic properties of regulatory circuits.
From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology >
Julian Lewis
Modeling of biochemical regulatory circuits reveals new insights into old problems in development.

In Science Signaling

EDITORIAL GUIDE

Focus Issue: From Input to Output--Are All Paths Equal? >
Nancy R. Gough
The consequences of various input signals must first be understood to gain a systems-level explanation of signaling networks.

PERSPECTIVES

Systems- and Molecular-Level Elucidation of Signaling Processes Through Chemistry >
Kyle P. Chiang and Tom W. Muir
New techniques take advantage of chemistry to investigate signal transduction mechanisms in the cell.
A Scaffold Makes the Switch >
Henrik G. Dohlman
The location of a scaffolding protein determines whether activation of MAPK signaling in yeast will produce a graded or binary response.

PERSPECTIVES

Probing Pathways Periodically >
Timothy C. Elston
Monitoring the response to periodic input signals reveals dynamic properties of a MAPK pathway.

RESEARCH ARTICLE

Fault Diagnosis Engineering of Digital Circuits Can Identify Vulnerable Molecules in Complex Cellular Pathways >
Ali Abdi, Mehdi Baradaran Tahoori, Effat S. Emamian
An engineering approach reveals the weakest links in cellular signaling networks.

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)